The biggest city of pakistan city has come to a near standstill following the killing in London of an exiled leader of the powerful Muttahida Qaumi Movement.
MQM supporters have gathered in Karachi to mourn Imran Farooq, who was stabbed outside his home on Thursday afternoon.
A BBC correspondent in the city says the situation is tense, with most shops, restaurants and schools closed.
The murder investigation has meanwhile been taken over by the Metropolitan Police's counter-terrorism unit, SO15.
The BBC's home affairs correspondent, Danny Shaw, says although no-one has yet been arrested over the stabbing of Mr Farooq, the working assumption at this stage is that it was politically motivated.

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